In a press conference in April 2020, President Trump claimed that Hydroxychloroquine showed "tremendous promise" as a treatment for Covid-19. This statement prompted the media, to slam his statement as false, Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases (NIAID) emphatically claimed that Hydroxychloroquine was nothing more than anecdotal and had no significant effect in the treatment of Covid-19.
The media however neglected to do their due diligence in investigating this comment from President Trump, instead opting to take the opinion of the efficacy of Hydroxychloroquine from a health expert who has been employed by the government since 1984.
In an article written by PNAS Proceedings of the national academy of sciences of the United States of America, in 2005, it was discovered that SARS-CoV infection results from a unique, three-step process: receptor binding and induced conformational changes in S glycoprotein followed by cathepsin L proteolysis within endosomes. The requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitors for SARS-CoV infection. Indicating that inhibitors of cathepsin L could possibly stop Sars Covid-19 dead in its tracks.
"Cathepsin L (CatL) is an endosomal cysteine protease. It mediates the cleavage of the S1 subunit of the coronavirus surface spike glycoprotein. This cleavage is necessary for coronavirus entry into human host cells, virus and host cell endosome membrane fusion, and viral RNA release for next round of replication." Inhibiting CatL is the key to stopping Covid-19 from replicating in the body and preventing cytokine storms, an overreaction of the body's immune system.
What drugs have the possibility of inhibiting Cathepsin L? According to Pharmacology and Therapeutics, Top drug candidates.
"The announced results from in vitro tests and clinical feedback from case studies and news reports suggest possible efficacy of at least 4 drugs, including remdesivir, chloroquine, lopinavir/ritonavir, andarbidol, although detailed clinical trial data are pending."
According to Henry Ford Health System, Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side effects. “The findings have been highly analyzed and peer-reviewed,” said Dr. Marcus Zervos, division head of Infectious Disease for Henry Ford Health System, who co-authored the study with Henry Ford epidemiologist Samia Arshad. “We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring."
With clinical trials of HCQ being administered within 48 hours of symptoms, in vivo efficacy has been proven, and in vitro, proof that HCQ inhibits the spike protein from attaching itself to cells, disabling its ability to replicate, why has no one in the media discussed the potential for treatment? Why is the Biden administration having people go door to door in a high-pressure campaign to get America vaccinated?
If the media had this information back in 2005 they allowed politics to get in the way of valuable health information that could have saved millions of lives. Furthermore, there has been a concerted effort to suppress any information other than full vaccination on all social media. Should they be held accountable? WECU wants to know.